A CASE OF GLOMERULOID HEMANGIOMA ASSOCIATED WITH MULTICENTRIC CASTLEMANS-DISEASE

Glomeruloid hemangioma is a term that was coined J.K.C. Chan and colle agues in 1990 because the condition is histopathologically similar to renal glomeruli. In the three cases described to date, there have been signs of POEMS syndrome of multicentric Castleman's disease. We prese nt the case of a 44-year-old Korean woman who developed glomeruloid he mangioma in association with multicentric Castleman's disease and some features of POEMS syndrome. It is interesting that in this patient, t he first biopsy specimen revealed an immature vascular tumor that coul d not be precisely classified and the second indicated glomeruloid hem angioma. The present case may lend support to the suggestion that in P OEMS disease, some types of vascular proliferations develop in respons e to angiogenic stimuli that show a spectrum of histopathologic featur es, and glomeruloid hemangioma is one of the reactive vascular prolife rations. We believe that the primitive vascular tumor seen in the firs t biopsy specimen may be the most immature stage of this spectrum.