Ee. Patton et al., COMBINATORIAL CONTROL IN UBIQUITIN-DEPENDENT PROTEOLYSIS - DONT SKP THE F-BOX HYPOTHESIS, Trends in genetics, 14(6), 1998, pp. 236-243
The ubiquitin-dependent proteolytic pathway targets many key regulator
y proteins for rapid intracellular degradation Specificity in protein
ubiquitination derives from E3 ubiquitin protein ligases, which recogn
ize substrate proteins. Recently, analysis of the E3s that regulate ce
ll division has revealed common themes in structure and function. One
particularly versatile class of E3s, referred to ns Skp1p-Cdc53p-F-box
protein (SCF) complexes, utilizes substrate-specific adaptor subunits
called F-box proteins to recruit various substrates to a core ubiquit
ination complex. A vast array of F-box proteins have been revealed by
genome sequencing projects, aad the early returns from genetic analysi
s in several organisms promise that F-box proteins will participate il
l the regulation of many processes, including cell division transcript
ion, signal transduction and development.