BACTERIAL BIOTRANSFORMATION OF 3-ALPHA(S)-STRICTOSIDINE TO THE MONOTERPENOID INDOLE ALKALOID VALLESIACHOTAMINE

Authors
SHEN ZQ EISENREICH W KUTCHAN TM
Citation
Zq. Shen et al., BACTERIAL BIOTRANSFORMATION OF 3-ALPHA(S)-STRICTOSIDINE TO THE MONOTERPENOID INDOLE ALKALOID VALLESIACHOTAMINE, Phytochemistry, 48(2), 1998, pp. 293-296
Citations number
14
Categorie Soggetti
Biology,"Plant Sciences
Journal title
Phytochemistry → ACNP
ISSN journal
00319422
Volume
48
Issue
2
Year of publication
1998
Pages
293 - 296
Database
ISI
SICI code
0031-9422(1998)48:2<293:BBO3TT>2.0.ZU;2-8
Abstract
3 alpha(S)-Strictosidine produced by heterologously expressed strictos idine synthase from Rauwolfia serpentina was used in biotransformation experiments with a series of 22 bacterial strains. All strains tested were found to deglucosylate and rearrange the alkaloid to vallesiacho tamine, thereby providing an example of how gene technology and microb ial biotransformation can be combined for the biotechnological product ion of alkaloidal natural products. (C) 1998 Elsevier Science Ltd. All rights reserved.