Zq. Shen et al., BACTERIAL BIOTRANSFORMATION OF 3-ALPHA(S)-STRICTOSIDINE TO THE MONOTERPENOID INDOLE ALKALOID VALLESIACHOTAMINE, Phytochemistry, 48(2), 1998, pp. 293-296
3 alpha(S)-Strictosidine produced by heterologously expressed strictos
idine synthase from Rauwolfia serpentina was used in biotransformation
experiments with a series of 22 bacterial strains. All strains tested
were found to deglucosylate and rearrange the alkaloid to vallesiacho
tamine, thereby providing an example of how gene technology and microb
ial biotransformation can be combined for the biotechnological product
ion of alkaloidal natural products. (C) 1998 Elsevier Science Ltd. All
rights reserved.