Sl. Kaufman, ANALYSIS OF BIOMOLECULES USING ELECTROSPRAY AND NANOPARTICLE METHODS - THE GAS-PHASE ELECTROPHORETIC MOBILITY MOLECULAR ANALYZER (GEMMA), Journal of aerosol science, 29(5-6), 1998, pp. 537-552
Aerosol particle detection and sizing techniques have recently been ex
tended downwards to a size range commensurate with the size of many im
portant biomolecules. Although such large molecules do not naturally o
ccur individually as aerosol particles, electrospray-drying makes it F
easible to generate an aerosol of isolated single macromolecules from
macromolecule solutions. The combination of this electrospray generati
on with the improved aerosol techniques makes possible a new method of
size analysis for biomolecules. We present characteristics of this ne
w system and review some recent results. (C) 1998 Elsevier Science Ltd
. All rights reserved.