History and clinical findings: Two women (aged 21 and 44 years) were r
eferred because of a suspect retinal lesion. An ophthalmological exami
nation in both revealed prominent retinal granulomatous foci, probably
ocular toxocariasis. Both women were otherwise well; both reported cl
ose contact with dogs. investigations: Among a full array of laborator
y tests the only major pathologic findings were high antibody titres a
gainst Toxocara canis (patient 1: 70 antibody units [AU]; patient 2: >
100 AU), specific antibodies in the ELISA and Western blot tests conf
irming the diagnosis of T. canis infection. Diagnosis, treatment and c
ourse: Both patients were treated with prednisolone (initially 75 mg/d
, gradually decreasing over 4 months) and albendazole (Z x 800 mg/d fo
r 6 days), with complete healing of the chorioretinal foci, Conclusion
: General physicians as well as ophthalmologists should more often inc
lude Toxocara canis infection in the differential diagnosis, because t
he larvae, in their migration through the body, can infest various org
ans where they can cause inflammatory or allergic reactions.