RISK-FACTORS FOR CONGENITAL-SYPHILIS IN INFANTS OF WOMEN WITH SYPHILIS IN SOUTH-CAROLINA

Objectives. This study examined risk factors for congenital syphilis i n South Carolina. Methods. Case infants with presumptive and confirmed congenital syphilis were compared with control infants born to women with reactive serologies during pregnancy, allowing investigation of r isk factors for congenital rather than acquired transmission of syphil is. Data were collected from congenital syphilis report forms and birt h certificates for 186 case infants and 487 controls born from 1991 to 1993. Odds ratios were calculated for maternal risk factors. Results. Significant statistical trends were found for timing of first prenata l visit and number of visits. Other significant factors included rural residence (odds ratio [OR] = 2.0, 95% confidence interval [CI] = 1.4, 2.9) and previous pregnancy loss (OR = 0.3, 95% CI = 0.2, 0.6). Concl usions. Prevention of congenital syphilis may be less effective among pregnant women with syphilis in South Carolina who have fewer prenatal care visits. Health care providers need further education on maternal /child syphilis management and techniques for motivating and educating patients.