THERAPEUTIC POTENTIAL HISTAMINE H-3 RECEPTOR AGONISTS AND ANTAGONISTS

The histamine H-3 receptor was discovered 15 years ago, and many poten t and selective H-3, receptor agonists and antagonists have since been developed. Currently, much attention is being focused on the therapeu tic potential of H-3 receptor ligands. In this review, Rob Leurs, Patr izio Blandina, Clark Tedford and Henk Timmerman describe the available H-3 receptor agonists and antagonists and their effects in a variety of pharmacological models in vitro and in vivo. The possible therapeut ic applications of the various compounds are discussed.