AN EFFICIENT SYNTHESIS OF TETRAETHYL FLUOROMETHYLENEDIPHOSPHONATE ANDDERIVATIVES FROM DIETHYL DIBROMOFLUOROMETHYLPHOSPHONATE

Authors
IORGA B EYMERY F SAVIGNAC P
Citation
B. Iorga et al., AN EFFICIENT SYNTHESIS OF TETRAETHYL FLUOROMETHYLENEDIPHOSPHONATE ANDDERIVATIVES FROM DIETHYL DIBROMOFLUOROMETHYLPHOSPHONATE, Tetrahedron letters, 39(25), 1998, pp. 4477-4480
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
25
Year of publication
1998
Pages
4477 - 4480
Database
ISI
SICI code
0040-4039(1998)39:25<4477:AESOTF>2.0.ZU;2-X
Abstract
Treatment of diethyl I,1-dibromo-1-fluoromethylphosphonate with n-BuLi (1:1) at low temperature affords by self-trapping in quantitative yie ld the lithiated derivative of tetraethyl fluoromethylenediphosphonate which is reacted with alkylating and halogenating agents or converted with high selectivity into (E) diethyl fluorovinylphosphonates by rea ction with carbonyl compounds. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.