DIRECT SYNTHESIS OF AMIDES FROM CARBOXYLIC-ACIDS AND AMINES WITH BENZENESULFONYL CHLORIDE AS REAGENT IN AQUEOUS-MEDIUM

Various amides have been prepared by a direct condensation reaction be tween carboxylic acids and amines in aqueous medium, using benzenesulf onyl chloride as reagent. The occurrence of this reaction in the prese nce of water is a proof that the mixt anhydrides, which result ''in si tu'' as intermediary products, have a relative stability to hydrolysis and can react with amines affording amides in moderate yields. This r eaction has a biological importance, because the synthesis of amidic b ond in living organisms occurs also in the presence of water.