A. Felinger et G. Guiochon, RAPID SIMULATION OF CHROMATOGRAPHIC BAND PROFILES ON PERSONAL COMPUTERS, Journal of chromatography, 658(2), 1994, pp. 511-515
The calculating power and speed of microcomputers has rapidly increase
d during the last few years, while their cost has decreased almost as
fast. As a result, it has become possible for most chromatographers to
calculate rapidly the individual elution band profiles of the compone
nts of mixtures by integrating the differential mass balance equation
of chromatography. It has become possible to find out rapidly what wou
ld be the effect of possible modifications of the experimental paramet
ers. For conventional columns having a few thousand plates, the comput
ation takes between a few seconds and a few minutes, provided a perfor
ming algorithm is used.