Objective: Bronchogenic and esophageal duplication cysts are congenita
l anomalies of the tracheobronchial tree and foregut that are often as
ymptomatic at initial presentation in adults. Surgery is always recomm
ended, even for patients with asymptomatic disease, because of the pos
sible development of symptoms and complications during the natural cou
rse of the disease and because definitive diagnosis can be established
only on surgical specimen. Methods: Twenty-seven patients with bronch
ogenic and esophageal duplication cysts were treated in our institutio
n over the last 2 decades. Ten patients (37%) were asymptomatic at ini
tial presentation. Chest pain and dysphagia were the most common compl
aints in symptomatic patients affected by bronchogenic and duplication
cysts, respectively. Results: A complete excision of the cyst was per
formed in 26 cases, whereas one patient with intrapulmonary cyst under
went a right upper pulmonary lobectomy. A posterolateral thoracotomy w
as performed in 23 patients, and a video-assisted thoracoscopy using a
three-port technique was performed in the last 4 patients. No postope
rative morbidity was recorded. All patients, except one, were asymptom
atic at a median follow-up time of 4 years. Conclusions: Surgery is th
e treatment of choice for bronchogenic and esophageal duplication cyst
s. Video-assisted thoracoscopy should represent the first-line approac
h in these patients.