Whole-lung lavage is the only efficient treatment in pulmonary alveola
r proteinosis. A 36-year-old woman with severe pulmonary alveolar prot
einosis confirmed by video-assisted thoracoscopic lung biopsies underw
ent repetitive whole-lung lavages without improvement. A modified tech
nique consisting of manual ventilation between instillation and aspira
tion of half the amount of saline used for conventional lavage was app
lied. Impressive clinical and functional improvement occurred and pers
isted for 1 year. We believe that the amelioration can be attributed t
o the technique described above.