A2REL - A CONSTITUTIVELY EXPRESSED LEISHMANIA GENE LINKED TO AN AMASTIGOTE-STAGE-SPECIFIC GENE

Authors
GHEDIN E CHAREST H MATLASHEWSKI G
Citation
E. Ghedin et al., A2REL - A CONSTITUTIVELY EXPRESSED LEISHMANIA GENE LINKED TO AN AMASTIGOTE-STAGE-SPECIFIC GENE, Molecular and biochemical parasitology, 93(1), 1998, pp. 23-29
Citations number
13
Categorie Soggetti
Parasitiology,Biology
Journal title
Molecular and biochemical parasitology → ACNP
ISSN journal
01666851
Volume
93
Issue
1
Year of publication
1998
Pages
23 - 29
Database
ISI
SICI code
0166-6851(1998)93:1<23:A-ACEL>2.0.ZU;2-F
Abstract
The A2-A2rel gene copies are arranged in tandem arrays on a 850 kb chr omosome in Leishmania donovani. Contrary to A2 mRNA which displays ama stigote-stage-specific expression, A2rel gene expression is constituti ve throughout the L. donovani life cycle. The A2rel sequence was found to be conserved in all Leishmania species tested, while the A2 sequen ce is specific to L. donovani and L. mexicana. The A2rel full length c DNA is of 2.3 kb and it contains one open reading frame coding for a p utative protein of 436 amino acids. (C) 1998 Elsevier Science B.V. All rights reserved.