GENOMIC ORGANIZATION AND MAPPING OF THE HUMAN ACTIVIN RECEPTOR-TYPE IIB (HACTR-IIB) GENE

Authors
ISHIKAWA S KAI M MURATA Y TAMARI M DAIGO Y MURANO T OGAWA M NAKAMURA Y
Citation
S. Ishikawa et al., GENOMIC ORGANIZATION AND MAPPING OF THE HUMAN ACTIVIN RECEPTOR-TYPE IIB (HACTR-IIB) GENE, JOURNAL OF HUMAN GENETICS, 43(2), 1998, pp. 132-134
Citations number
18
Categorie Soggetti
Genetics & Heredity
Journal title
JOURNAL OF HUMAN GENETICS → ACNP
ISSN journal
14345161
Volume
43
Issue
2
Year of publication
1998
Pages
132 - 134
Database
ISI
SICI code
1434-5161(1998)43:2<132:GOAMOT>2.0.ZU;2-7
Abstract
Activins, members of a family of proteins that includes transforming g rowth factor-beta (TGF-beta), are gonadal polypeptide hormones that st imulate secretion of follicle-stimulating hormone (FSH). During large- scale sequencing analysis of a 1.2-Mb fragment of human genomic DNA on 3p22-p21.3, we found the gene encoding activin receptor type IIB (hAc tR-IIB). Comparison of its reported cDNA sequence with this genomic se quence showed that the hActR-IIB gene consists of 11 exons and spans a bout 30 kb of genomic DNA.