SOLUBILITY CORRELATION OF STRUCTURALLY RELATED DRUGS IN BINARY SOLVENT MIXTURES

Applicability of the well-established cosolvency equation, i.e. combin ed nearly ideal binary solvent/Redlich-Kister, CNIBS/R-K, model for ca lculating the solubility of structurally related drugs in a given coso lvent and water mixtures is presented. The accuracy and predictability of the model are also compared with those of two other models. Comput ational results show that the CNIBS/R-K model provides very reasonable solubility predictions for the solutes considered, and the CNIBS/R-K model is superior to the other two models. (C) 1998 Elsevier Science B .V. All rights reserved.