CLOZAPINE FOR THE TREATMENT OF AGITATED-DEPRESSED PATIENTS WITH COGNITIVE IMPAIRMENT - A REPORT OF 3 CASES

Clozapine, an atypical antipsychotic, is mainly approved for the treat ment of resistant schizophrenia. However, a substantial body of eviden ce suggests that it might be useful in other psychiatric indications, such as treatment-resistant depression, Parkinson's disease, and demen tia. In this report we present the cases of three patients hospitalize d at the psychiatric division of the Sheba Medical Center, diagnosed w ith major depressive disorder with cognitive impairment, whose present ing symptom was agitation. These patients were nonresponders to variou s treatment modalities. However, treatment with clozapine brought abou t a favorable response.