Benzodiazepine withdrawal delirium is thought to be uncommon. Only two
clear reports of alprazolam withdrawal appear in the literature, but
the use of this drug is expected to increase because of its recent app
roval for the treatment of panic disorder. We report on a patient with
severe alprazolam withdrawal delirium that developed immediately afte
r an accidental reduction of the dose. This case demonstrates importan
ce of clinician awareness of the previous use of alprazolam in individ
ual patients, especially in hospital settings where free patient use o
f drugs is prohibited.