A NEW CONVENIENT ROUTE TO RADIOIODINATED N-SUCCINIMIDYL 3-IODOBENZOATE AND 4-IODOBENZOATE, 2 REAGENTS FOR RADIOIODINATION OF PROTEINS

Authors
KOZIOROWSKI J HENSSEN C WEINREICH R
Citation
J. Koziorowski et al., A NEW CONVENIENT ROUTE TO RADIOIODINATED N-SUCCINIMIDYL 3-IODOBENZOATE AND 4-IODOBENZOATE, 2 REAGENTS FOR RADIOIODINATION OF PROTEINS, Applied radiation and isotopes, 49(8), 1998, pp. 955-959
Citations number
28
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging","Chemistry Inorganic & Nuclear
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
49
Issue
8
Year of publication
1998
Pages
955 - 959
Database
ISI
SICI code
0969-8043(1998)49:8<955:ANCRTR>2.0.ZU;2-9
Abstract
A straightforward method for the synthesis of N-succinimidyl 3- and 4- [I-124]iodobenzoate (m- and p-[I-124]SIB) via destannylation has been developed. The stannylated precursor was obtained as a white crystalli ne solid in 80% overall yield from 3- or 4-iodobenzoic acid after a tw o step synthesis. Iodode-stannylation was performed with 4.2-d (25% be ta(+))I-124 and Iodogen or lodobeads as the oxidant yielding 90% of th e desired product. (C) 1998 Elsevier Science Ltd. All rights reserved.