A prospective cohort study was conducted among chronic injecting and c
rack cocaine drug using women. The hypothesis tested was that particip
ation in a standard-plus-innovative intervention was more likely to pr
oduce behavior change than participation in a standard intervention. S
tandardized intervention protocols and corresponding instruments were
designed. Data were collected on drug and sex risk behaviors at baseli
ne and six-month follow-up intervals. The level of behavioral change i
n two intervention arms-standard and a standard-plus-innovative interv
ention-was measured by composite sex risk and drug risk scores using t
he generalized estimating equation approach. The results show that on
four risk measures the enhanced intervention was significantly associa
ted with positive change in both drug use and sexual behavior: less fr
equent drug use, less drug use during sex, and more frequent condom us
e during particular frequencies for specific types of sexual activitie
s. Public health interventions are effective when targeting specific r
isk behaviors through interventions tailored to prevent HIV and reduce
risk behaviors among specific cultural and gender groups.