CLONING AND SEQUENCE-ANALYSIS OF HSP89-ALPHA-DELTA-N, A NEW MEMBER OFTHE HSP90 GENE FAMILY

Authors
SCHWEINFEST CW GRABER MW HENDERSON KW PAPAS TS BARON PL WATSON DK
Citation
Cw. Schweinfest et al., CLONING AND SEQUENCE-ANALYSIS OF HSP89-ALPHA-DELTA-N, A NEW MEMBER OFTHE HSP90 GENE FAMILY, Biochimica et biophysica acta, N. Gene structure and expression, 1398(1), 1998, pp. 18-24
Citations number
11
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta, N. Gene structure and expression → ACNP
ISSN journal
01674781
Volume
1398
Issue
1
Year of publication
1998
Pages
18 - 24
Database
ISI
SICI code
0167-4781(1998)1398:1<18:CASOHA>2.0.ZU;2-4
Abstract
We have identified a novel member of the Hsp90 gene family. This new g ene, Hsp89 alpha Delta N, is remarkable in that it appears to represen t a recent evolutionary event. Hsp89 alpha Delta N is identical in nuc leotide sequence to Hsp89 alpha for codons 224 to 732 (end). However, Hsp89 alpha Delta N cDNA lacks the ATP/geldanamycin binding domain (co dons 1-220), instead containing 544 nucleotides of unique DNA at its 5 ' end including 30 novel codons. (C) 1998 Elsevier Science B.V. All ri ghts reserved.