SYNTHESIS OF FLUORESCENT SUBSTRATES FOR PROTEIN-TYROSINE-PHOSPHATASE ASSAYS

Authors
WATANABE T IMOTO M TANIGUCHI H KINOSHITA K UMEZAWA K
Citation
T. Watanabe et al., SYNTHESIS OF FLUORESCENT SUBSTRATES FOR PROTEIN-TYROSINE-PHOSPHATASE ASSAYS, Bioorganic & medicinal chemistry letters, 8(11), 1998, pp. 1301-1302
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
11
Year of publication
1998
Pages
1301 - 1302
Database
ISI
SICI code
0960-894X(1998)8:11<1301:SOFSFP>2.0.ZU;2-Q
Abstract
Two fluorescent substrates for protein tyrosine phosphatase (PTPase) r eaction were prepared by conjugation of commercially available O-phosp hotyrosine and dansyl chlorides. They were hydrolyzed by CD45 tyrosine phosphatase, and proved to be useful for PTPase assay. (C) 1998 Elsev ier Science Ltd. All rights reserved.