ACTIVATION AND STABILIZATION OF CHYMOTRYPSIN IN MICRODOMAINS OF POLY(ETHYLENIMINE) DERIVATIVES - A MODEL OF IN-VIVO ENVIRONMENT

Authors
SUH J LEE YS HAN S
Citation
J. Suh et al., ACTIVATION AND STABILIZATION OF CHYMOTRYPSIN IN MICRODOMAINS OF POLY(ETHYLENIMINE) DERIVATIVES - A MODEL OF IN-VIVO ENVIRONMENT, Bioorganic & medicinal chemistry letters, 8(11), 1998, pp. 1331-1336
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
11
Year of publication
1998
Pages
1331 - 1336
Database
ISI
SICI code
0960-894X(1998)8:11<1331:AASOCI>2.0.ZU;2-Q
Abstract
Both activity and stability of alpha-Chymotrypsin (ChT) are substantia lly enhanced in the microdomains of laurylated or benzylated derivativ es of poly(ethylenimine). EPR data revealed that the enhancement in ac tivity of ChT is due to increase in the polarity of the microenvironme nt of Ser-195 caused by complexation of ChT to the polymer derivatives . (C) 1998 Elsevier Science Ltd. All rights reserved.