SYNTHESIS AND BIOLOGICAL EVALUATION OF 1,2-DISUBSTITUTED CARBONUCLEOSIDES OF 2-AMINO-6-SUBSTITUTED PURINE AND 8-AZAPURINE

Authors
SANTANA L TEIJEIRA M URIARTE E BALZARINI J DECLERCQ E
Citation
L. Santana et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF 1,2-DISUBSTITUTED CARBONUCLEOSIDES OF 2-AMINO-6-SUBSTITUTED PURINE AND 8-AZAPURINE, Bioorganic & medicinal chemistry letters, 8(11), 1998, pp. 1349-1352
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
11
Year of publication
1998
Pages
1349 - 1352
Database
ISI
SICI code
0960-894X(1998)8:11<1349:SABEO1>2.0.ZU;2-9
Abstract
One, two-disubstituted carbocyclic nucleoside analogues bearing a 2-am ino-6-substituted (chloro, hydroxy or amino) purine or 8-azapurine bas e were prepared by constructing the base about (+/-)-2-aminocyclopenta ne methanol, and their activities against a selection of viruses and t umor cells were determined in vitro. (C) 1998 Elsevier Science Ltd. Al l rights reserved.