SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW TETRAHYDRONAPHTHALENE DERIVATIVES AS THROMBOXANE RECEPTOR ANTAGONISTS

Authors
CIMETIERE B DUBUFFET T MULLER O DESCOMBES JJ SIMONET S LAUBIE M VERBEUREN TJ LAVIELLE J
Citation
B. Cimetiere et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW TETRAHYDRONAPHTHALENE DERIVATIVES AS THROMBOXANE RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 8(11), 1998, pp. 1375-1380
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
11
Year of publication
1998
Pages
1375 - 1380
Database
ISI
SICI code
0960-894X(1998)8:11<1375:SABEON>2.0.ZU;2-C
Abstract
New polysubstituted tetrahydronaphthalene derivatives were prepared as thromboxane receptor (TP-receptor) antagonists. Within this series of compounds S 18886 has been identified as an orally active, highly pot ent antagonist with a very long duration of action in different specie s. (C) 1998 Elsevier Science Ltd. All rights reserved.