THE NOVEL CYCLOPROPAPYRROLOINDOLE(CPI) BISALKYLATORS BEARING METHOXYCARBONYL AND TRIFLUOROMETHYL GROUPS

Authors
FUKUDA Y FURUTA H KUSAMA Y EBISU H OOMORI Y TERASHIMA S
Citation
Y. Fukuda et al., THE NOVEL CYCLOPROPAPYRROLOINDOLE(CPI) BISALKYLATORS BEARING METHOXYCARBONYL AND TRIFLUOROMETHYL GROUPS, Bioorganic & medicinal chemistry letters, 8(11), 1998, pp. 1387-1390
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
11
Year of publication
1998
Pages
1387 - 1390
Database
ISI
SICI code
0960-894X(1998)8:11<1387:TNCBBM>2.0.ZU;2-S
Abstract
The novel ycarbonyl-2-trifluoromethylcyclopropapyrroloindole (MCTFCPI) bisalkylators were synthesized and their antitumor activity was evalu ated. Among these derivatives, 7f in which two MCTFCPI moieties are co nnected with a 5,5'-bis(2-carbonyl-1 H-indole) group, was found to exh ibit more prominent cytotoxicity and antitumor activity than U-77,779 (bizelesin) (2). (C) 1998 Elsevier Science Ltd. All rights reserved.