NOVEL D-RING ANALOGS OF PODOPHYLLOTOXIN AS POTENT ANTICANCER AGENTS

Authors
SUBRAHMANYAM D RENUKA B RAO CVL SAGAR PS DEEVI DS BABU JM VYAS K
Citation
D. Subrahmanyam et al., NOVEL D-RING ANALOGS OF PODOPHYLLOTOXIN AS POTENT ANTICANCER AGENTS, Bioorganic & medicinal chemistry letters, 8(11), 1998, pp. 1391-1396
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
11
Year of publication
1998
Pages
1391 - 1396
Database
ISI
SICI code
0960-894X(1998)8:11<1391:NDAOPA>2.0.ZU;2-F
Abstract
Several D-ring modified analogues of podophyllotoxin were prepared viz semi-synthesis starting from naturally occuring podophyllotoxin and d etermined their in vitro anti-cancer activity. Most of the analogues h ave shown good activity towards human cancer cell lines. (C) 1998 Else vier Science Ltd. All rights reserved.