NOVEL CONSTRAINED CCK-B DIPEPTOID ANTAGONISTS DERIVED FROM PIPECOLIC ACID

Authors
BELLIER B DANASCIMENTO S MEUDAL H GINCEL E ROQUES BP GARBAY C
Citation
B. Bellier et al., NOVEL CONSTRAINED CCK-B DIPEPTOID ANTAGONISTS DERIVED FROM PIPECOLIC ACID, Bioorganic & medicinal chemistry letters, 8(11), 1998, pp. 1419-1424
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
11
Year of publication
1998
Pages
1419 - 1424
Database
ISI
SICI code
0960-894X(1998)8:11<1419:NCCDAD>2.0.ZU;2-X
Abstract
A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as mod erately potent CCK-B antagonists but their constrained structure and i ts comparison with structurally related compounds yield valuable infor mation about the conformational requirements for optimal recognition o f the CCK-B receptor by antagonists. (C) 1998 Elsevier Science Ltd. Al l rights reserved.