SYNTHESIS AND ANTIVIRAL ACTIVITY OF 2'-FLUOROHEXOPYRANOSYL NUCLEOSIDES

2'-Fluorohexopyranosyl nucleosides la and Ib which contained a bioisos teric double bond and a fluorine were synthesized in 12 steps, startin g from D-galactose. During diethylaminosulfur trifluoride (DAST) fluor ination, retention of stereochemistry was observed through the partici pation of methoxy or chloro group at the 6-position of the purine base . The final nucleosides 1a and 1b were found to be inactive against HI V-1 and HSV-1,2.