The moderately halophilic heterotrophic aerobic bacteria form a divers
e group of microorganisms. The property of halophilism is widespread w
ithin the bacterial domain. Bacterial halophiles are abundant in envir
onments such as salt lakes, saline soils, and salted food products. Mo
st species keep their intracellular ionic concentrations at low levels
while synthesizing or accumulating organic solutes to provide osmotic
equilibrium of the cytoplasm with the surrounding medium. Complex mec
hanisms of adjustment of the intracellular environments and the proper
ties of the cytoplasmic membrane enable rapid adaptation to changes in
the salt concentration of the environment. Approaches to the study of
genetic processes have recently been developed for several moderate h
alophiles, opening the way toward an understanding of haloadaptation a
t the molecular level. The new information obtained is also expected t
o contribute to the development of novel biotechnological uses for the
se organisms.