Skepticism has surrounded the existence of branchial cleft carcinoma s
ince the entity was first described in 1882. However, a landmark work
of 1950 established four criteria for the diagnosis of branchial cleft
carcinoma, the most important criterion being histologic proof of car
cinoma arising from a normal cyst epithelium. Of the 43 cases found in
an extensive review of the literature, only 7 cases have satisfied al
l four of the criteria. To this we add 2 patients who had recurrent in
fections of a cervical cyst as children and later developed carcinoma
within these structures. Additionally, we propose a minor modification
to the 1950 criteria and a paradigm for diagnosis and management of t
hese lesions.