SECONDARY THROMBIN-BINDING SITE, GLYCOSAMINOGLYCAN BINDING DOMAIN ANDREACTIVE CENTER REGION OF LEUSERPIN-2 ARE STRONGLY CONSERVED IN MAMMALIAN-SPECIES

Authors
WESTRUP D RAGG H
Citation
D. Westrup et H. Ragg, SECONDARY THROMBIN-BINDING SITE, GLYCOSAMINOGLYCAN BINDING DOMAIN ANDREACTIVE CENTER REGION OF LEUSERPIN-2 ARE STRONGLY CONSERVED IN MAMMALIAN-SPECIES, Biochimica et biophysica acta, N. Gene structure and expression, 1217(1), 1994, pp. 93-96
Citations number
12
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta, N. Gene structure and expression → ACNP
ISSN journal
01674781
Volume
1217
Issue
1
Year of publication
1994
Pages
93 - 96
Database
ISI
SICI code
0167-4781(1994)1217:1<93:STSGBD>2.0.ZU;2-P
Abstract
Using a combination of conventional and inverse polymerase chain react ion the cDNA structure coding for the thrombin inhibitor leuserpin-2 f rom rat has been determined. The rat genome specifies leuserpin-2 mRNA s differing in their 5'-untranslated regions probably due to alternati ve splicing of the primary transcript. Comparisons of partial sequence s from five different mammalian species show that the secondary thromb in binding site, the glycosaminoglycan binding domain and the reactive center region of the inhibitor are strongly conserved.