DIFFERENTIAL EXPRESSION OF INSULIN-RECEPTOR TYROSINE KINASE INHIBITOR(FETUIN) GENE IN A MODEL OF DIET-INDUCED OBESITY

Authors
LIN X BRAYMER HD BRAY GA YORK DA
Citation
X. Lin et al., DIFFERENTIAL EXPRESSION OF INSULIN-RECEPTOR TYROSINE KINASE INHIBITOR(FETUIN) GENE IN A MODEL OF DIET-INDUCED OBESITY, Life sciences, 63(2), 1998, pp. 145-153
Citations number
36
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
63
Issue
2
Year of publication
1998
Pages
145 - 153
Database
ISI
SICI code
0024-3205(1998)63:2<145:DEOITK>2.0.ZU;2-7
Abstract
The Differential Display technique has been used to identify differenc es in mRNA expression in adipose tissue after the introduction of a hi gh fat diet to two strains of rat (OM and S5B/PI) that differ in their susceptibility to develop obesity on this diet. The insulin receptor tyrosine kinase inhibitor protein (fetuin) was shown to be differentia lly expressed in OM but not S5B/PI rats. This circulating protein may play a role in the development of peripheral insulin resistance associ ated with high fat diets.