SPECTROPHOTOMETRIC DETERMINATION OF SOME ANTIBACTERIAL DRUGS USING P-NITROPHENOL

A simple, quick and sensitive spectrophotomettic method for pipemidic acid, norfloxacin and ciprofloxacin lactate is described, based on a r eaction with p-nitrophenol in water medium, apparently by a charge-tra nsfer mechanism, to yield 1:1 complexes with analytically useful maxim um absorption at 404 nm, 407nm and 403nm. Optimum conditions for deter mination, linear calibration range and apparent molar absorptivities h ave been reported. The methods are highly accurate and have been succe ssfully applied to the determination of pipemidic acid, norfloxacin an d ciprofloxacin lactate in tablets. The results are in good agreement with the official methods.