APPLICATION OF THIOCYANATE COMPLEX OF TITANIUM (IV) TO THE EXTRACTIVESPECTROPHOTOMETRIC DETERMINATION OF AMITRIPTYLINE HYDROCHLORIDE

Amitriptyline hydrochloride reacts in acidic medium with the thiocyana te complex of titanium (IV) forming a yellow ion-association compound, insoluble in water but fairly soluble in a mixture of chloroform and butyl alcohol (4:1). The formation and extraction conditions of the co mpound are described. The compound was characterized by UV,VIS,IR and H-1 NMR spectrometry. The colored compound exhibits a maximum absorpti on at 360 nm. Under the optimum experimental conditions, amitriptyline hydrochloride was determined in the 3-60 mu g/cm(3) range with a rela tive standard deviation less than 0.5% (n=8). The proposed method was verified against the pharmacopoeial method and applied to the determin ation of amitriptyline hydrochloride in pharmaceuticals.