Color-coded duplex sonography is the main innovation in diagnostic ult
rasound in recent years. It allows quantification of tissue vascularit
y and appreciation of vascular morphology. Due to the unique thyroid h
ypervascularity in Graves' disease this diagnosis can be made with col
or Doppler sonography alone. The decrease of vascularity during the co
urse of disease is a relevant parameter throughout the follow-up. Hype
rvascularity is also observed within areas of inflammatory infiltratio
n in thyroiditis, but the level is lower than in Graves' disease. Sono
graphic differentiation of benign from malignant thyroid nodules is no
t possible yet. Color-coded duplex sonography is not useful in the ini
tial detection of parathyroid masses, but may be helpful in distinguis
hing parathyroid lesions from other cervical masses.