A SEQUENTIAL ELECTROCHEMICAL OXIDATION - OLEFIN METATHESIS STRATEGY FOR THE CONSTRUCTION OF BICYCLIC LACTAM BASED PEPTIDOMIMETICS

Authors
BEAL LM MOELLER KD
Citation
Lm. Beal et Kd. Moeller, A SEQUENTIAL ELECTROCHEMICAL OXIDATION - OLEFIN METATHESIS STRATEGY FOR THE CONSTRUCTION OF BICYCLIC LACTAM BASED PEPTIDOMIMETICS, Tetrahedron letters, 39(26), 1998, pp. 4639-4642
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
26
Year of publication
1998
Pages
4639 - 4642
Database
ISI
SICI code
0040-4039(1998)39:26<4639:ASEO-O>2.0.ZU;2-D
Abstract
A sequential electrochemical amide oxidation - ring closing olefin met athesis sequence has been used to overcome problems associated with th e synthesis of seven-membered ring lactam containing bicyclic peptidom imetics. The synthesis of several previously unavailable bicyclic lact am building blocks for constructing constrained thyroliberin analogs i s described. (C) 1998 Elsevier Science Ltd. All rights reserved.