RING-CLOSING METATHESIS STRATEGY TO UNSATURATED GAMMA-LACTONE AND DELTA-LACTONE - SYNTHESIS OF HYDROXYETHYLENE ISOSTERE FOR PROTEASE INHIBITORS

Authors
GHOSH AK CAPPIELLO J SHIN D
Citation
Ak. Ghosh et al., RING-CLOSING METATHESIS STRATEGY TO UNSATURATED GAMMA-LACTONE AND DELTA-LACTONE - SYNTHESIS OF HYDROXYETHYLENE ISOSTERE FOR PROTEASE INHIBITORS, Tetrahedron letters, 39(26), 1998, pp. 4651-4654
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
26
Year of publication
1998
Pages
4651 - 4654
Database
ISI
SICI code
0040-4039(1998)39:26<4651:RMSTUG>2.0.ZU;2-H
Abstract
Ring-closing olefin metathesis of acrylates derived from allylic and h ome allylic alcohols in the presence of the Grubbs' catalyst (10-15 mo l%) and titanium isopropoxide (0.3-3 equiv) provided ready access to a lpha, beta-unsaturated gamma- and delta-lactones and an important dipe ptide isostere intermediate. (C) 1998 Elsevier Science Ltd. An rights reserved.