THE INTERLEUKIN-17 GENE OF HERPESVIRUS SAIMIRI

Authors
KNAPPE A HILLER C NIPHUIS H FOSSIEZ F THURAU M WITTMANN S KUHN EM LEBECQUE S BANCHEREAU J ROSENWIRTH B FLECKENSTEIN B HEENEY J FICKENSCHER H
Citation
A. Knappe et al., THE INTERLEUKIN-17 GENE OF HERPESVIRUS SAIMIRI, Journal of virology, 72(7), 1998, pp. 5797-5801
Citations number
23
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
72
Issue
7
Year of publication
1998
Pages
5797 - 5801
Database
ISI
SICI code
0022-538X(1998)72:7<5797:TIGOHS>2.0.ZU;2-6
Abstract
In comparison to wild-type herpesvirus saimiri, viral interleukin-17 g ene knockout mutants have unaltered behavior regarding viral replicati on, T-cell transformation in vitro, and pathogenicity in cottontop tam arins. Thus, this gene is not required for T-cell lymphoma induction b ut may contribute to apathogenic viral persistence in the natural host , the squirrel monkey.