A RARE CASE OF 46,XX TRUE HERMAPHRODITISM WITH HIDDEN MOSAICISM WITH SEX-DETERMINING REGION-Y CHROMOSOME-BEARING CELLS IN THE GONADS

Authors
INOUE H NOMURA M YANASE T ICHINO I GOTO K IKUYAMA S TAKAYANAGI R NAWATA H
Citation
H. Inoue et al., A RARE CASE OF 46,XX TRUE HERMAPHRODITISM WITH HIDDEN MOSAICISM WITH SEX-DETERMINING REGION-Y CHROMOSOME-BEARING CELLS IN THE GONADS, Internal medicine, 37(5), 1998, pp. 467-471
Citations number
16
Categorie Soggetti
Medicine, General & Internal
Journal title
Internal medicine → ACNP
ISSN journal
09182918
Volume
37
Issue
5
Year of publication
1998
Pages
467 - 471
Database
ISI
SICI code
0918-2918(1998)37:5<467:ARCO4T>2.0.ZU;2-H
Abstract
The sex-determining region Y chromosome (SRY) triggers testis determin ation. We report a 46,XX true hermaphrodite who had ambiguous genitali a at birth. A laparotomy at one year of age revealed this patient to h ave a testis on the right side and an ovotestis on the left side. By p olymerase chain reaction analysis no SRY was detected in the DNA from the leukocytes but it was found in the DNA from the ovotestis, The hid den mosaicism with the Y-bearing cells in the gonads is likely the cau se of the dual gonads in this patient.