MODULATION OF K-CHANNELS IN P-NEURONS OF THE LEECH CNS BY PHOSPHORYLATION()

Authors
GOLDERMANN M HANKE W SCHLUE WR
Citation
M. Goldermann et al., MODULATION OF K-CHANNELS IN P-NEURONS OF THE LEECH CNS BY PHOSPHORYLATION(), Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 174(2), 1994, pp. 231-237
Citations number
17
Categorie Soggetti
Physiology
Journal title
Journal of comparative physiology. A, Sensory, neural, and behavioral physiology → ACNP
ISSN journal
03407594
Volume
174
Issue
2
Year of publication
1994
Pages
231 - 237
Database
ISI
SICI code
0340-7594(1994)174:2<231:MOKIPO>2.0.ZU;2-V
Abstract
Two types of potassium channels of identified (p-) neurones of the lee ch (Hirudo medicinalis) were investigated by using the patch-clamp tec hnique. The open-state probability of these channels in cell-attached patches can be reduced by addition of 5-hydroxytryptamine to the bath solution. After excising the patches the application of alkaline phosp hatase to the cytosolic face of the patch increases the open probabili ty. The 5-HT1A-receptor agonist buspirone mimics the effect of 5-HT Ou r experiments show that the effect of 5-HT might be due to a channel p hosphorylation via a 5-HT1A-receptor subtype.