Documentation of causality between repetitive motions and musculoskele
tal disorders calls for detailed understanding of the exposure variabl
es and the corresponding physiologic responses in the biologic tissues
. Quantification of the kinetics in some jobs characterized by repetit
ive motions is summarized with the physiologic responses in the muscle
s. Muscle activity pattern was studied in different shoulder muscles o
r muscle parts, and in elbow and wrist flexor muscles. Activity patter
n was dependent on the kinetics of the work requirements. This holds t
rue for the compound electromyographic signal and for single motor uni
ts. Low threshold motor units have been identified that are recruited
continuously, the so called Cinderella fibers. The physiologic consequ
ences of prolonged muscle fiber activity are reviewed, revealing mecha
nisms for the development of necrotic changes in the muscle, which sup
port the likelihood of work relatedness for musculoskeletal disorders.