EFFECT OF AN ABUNDANT HUMAN SKIN MELANOSOMAL 66 KDA PROTEIN (MP-66) ON MURINE TYROSINASE - ITS PHYSIOLOGICAL IMPLICATIONS ON MELANOGENESIS

Authors
BABU BR DIWAKAR G RAMAIAH A FATMA T
Citation
Br. Babu et al., EFFECT OF AN ABUNDANT HUMAN SKIN MELANOSOMAL 66 KDA PROTEIN (MP-66) ON MURINE TYROSINASE - ITS PHYSIOLOGICAL IMPLICATIONS ON MELANOGENESIS, Journal of Biosciences, 23(2), 1998, pp. 125-129
Citations number
23
Categorie Soggetti
Biology
Journal title
Journal of Biosciences → ACNP
ISSN journal
02505991
Volume
23
Issue
2
Year of publication
1998
Pages
125 - 129
Database
ISI
SICI code
0250-5991(1998)23:2<125:EOAAHS>2.0.ZU;2-O
Abstract
A single polypeptide protein (MP 66) of molecular weight 66kDa purifie d to homogeneity from melanosomes of normal skin epidermal melanocytes , was partially characterized. The isoelectric point of MP 66 is in th range of 7&BULL;3 to 7&BULL;6. This protein, which was shown to inhib it partially purified human skin tyrosinase activity at pH 6&BULL;8,al so inhibits murine tyrosinase of pH 6&BULL;8. However, at pH 5&BULL;0, it stimulates murine tyrosinase activity. The physiological implicati ons of these results are discussed.