MATHEMATICAL-MODEL FOR THE BLOOD-COAGULATION PROTHROMBIN TIME TEST

Authors
KHANIN MA RAKOV DV KOGAN AE
Citation
Ma. Khanin et al., MATHEMATICAL-MODEL FOR THE BLOOD-COAGULATION PROTHROMBIN TIME TEST, Thrombosis research, 89(5), 1998, pp. 227-232
Citations number
26
Categorie Soggetti
Hematology,"Peripheal Vascular Diseas
Journal title
Thrombosis research → ACNP
ISSN journal
00493848
Volume
89
Issue
5
Year of publication
1998
Pages
227 - 232
Database
ISI
SICI code
0049-3848(1998)89:5<227:MFTBPT>2.0.ZU;2-C
Abstract
A mathematical model for the prothrombin time test is proposed. The ti me course of clotting factor activation during coagulation was calcula ted, and the sensitivity of the test to a decrease in the concentratio ns of coagulation proteins or their activities was studied. The model predicts that only severe coagulation disorders connected with a more than five-fold decrease in the concentrations or activities of the blo od coagulation factors can be revealed by the test. (C) 1998 Elsevier Science Ltd.