CHEMOKINES, LYMPHOCYTES AND VIRUSES - WHAT GOES AROUND, COMES AROUND

Chemokines are believed to be the long-sought soluble mediators of sel ective lymphocyte recruitment. As most selectin-integrin interactions are nonselective, it is thought that the discrimination seen during ly mphocyte infiltration into tissues is brought about by the actions of distinct chemokines. Developments over the past year have demonstrated the expanding roles of these factors in lymphocyte chemoattraction; n ormal trafficking, and viral immunity.