A 47-year-old man with acquired immune deficiency syndrome was found t
o have disseminated Saccharomyces kluyveri infection. The yeast was is
olated from blood and cerebrospinal fluid. An autopsy revealed the pre
sence of the microorganism in many organs including liver, kidneys, pa
ncreas, spleen, lung, and brain. The case confirms a potential pathoge
nicity of yeasts of the genus Saccharomyces in patients with profound
immune deficiency, especially in advanced HIV infection.