The effects on performance of unattended stimulus-response spatial rel
ationships in choice reaction time tasks (i.e., the Simon effect) have
been attributed to automatic activation of the response ipsilateral t
o stimulus location. We tested this assumption using the lateralized r
eadiness potential (LRP). The response key labels changed randomly fro
m trial to trial and were presented either 400 Ins before (immediate-r
eaction trials) or 400 ms after (delayed-reaction trials) stimulus. Th
e critical lest for the automatic activation hypothesis was on delayed
-reaction trials, in which LRP deflections were expected in the interv
al between stimulus and response-key labels. Contrary to this predicti
on. there were no LRP signs of response activation within that interva
l.