THE CELLULAR-ORGANIZATION OF GENE-EXPRESSION

Authors
MISTELI T SPECTOR DL
Citation
T. Misteli et Dl. Spector, THE CELLULAR-ORGANIZATION OF GENE-EXPRESSION, Current opinion in cell biology, 10(3), 1998, pp. 323-331
Citations number
105
Categorie Soggetti
Cell Biology
Journal title
Current opinion in cell biology → ACNP
ISSN journal
09550674
Volume
10
Issue
3
Year of publication
1998
Pages
323 - 331
Database
ISI
SICI code
0955-0674(1998)10:3<323:TCOG>2.0.ZU;2-U
Abstract
Recent cell biological observations have provided new insights into ho w transcription, pre-mRNA splicing and 3' processing are organized and coordinated with each other in the mammalian cell nucleus. Morphologi cal observations are supported by biochemical evidence that suggests p hysical interactions between components of the transcription and RNA p rocessing machineries. A working model of the cellular organization of gene expression is now emerging.