IMMUNOHISTOCHEMICAL LOCALIZATION OF METALLOTHIONEIN IN HEPATOCELLULAR-CARCINOMA - PREFERENTIAL EXPRESSION IN NONCANCEROUS CIRRHOTIC NODULES

Authors
TANIMOTO K AKBAR SMF YAMAUCHI Y MICHITAKA K HORIIKE N ONJI M
Citation
K. Tanimoto et al., IMMUNOHISTOCHEMICAL LOCALIZATION OF METALLOTHIONEIN IN HEPATOCELLULAR-CARCINOMA - PREFERENTIAL EXPRESSION IN NONCANCEROUS CIRRHOTIC NODULES, Oncology Reports, 5(4), 1998, pp. 805-809
Citations number
13
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
5
Issue
4
Year of publication
1998
Pages
805 - 809
Database
ISI
SICI code
1021-335X(1998)5:4<805:ILOMIH>2.0.ZU;2-2
Abstract
Metallothionein (MT), an oncofocal gene product was strongly expressed in 35%-95% of hepatocytes in hepatocellular carcinoma (HCC) and MT-po sitive hepatocytes were localized mainly in the non-cancerous cirrhoti c nodules but not in malignant hepatocytes. On the other hand, <10% he patocytes showed weak staining for MT in chronic hepatitis and cirrhos is of liver. Strong expressions of MT in noncancerous cirrhotic nodule in HCC and low expressions in liver cirrhosis without HCC indicate a relationship between malignant transformation of hepatocytes and the e xpression of MT.