DETECTION OF SERUM P53 ANTIBODIES IN PATIENTS WITH ESOPHAGEAL SQUAMOUS-CELL CARCINOMA - CORRELATION WITH CLINICOPATHOLOGICAL FEATURES AND TUMOR-MARKERS

Authors
SHIMADA H NAKAJIMA K OCHIAI T KOIDE Y OKAZUMI SI MATSUBARA H TAKEDA A MIYAZAWA Y ARIMA M ISONO K
Citation
H. Shimada et al., DETECTION OF SERUM P53 ANTIBODIES IN PATIENTS WITH ESOPHAGEAL SQUAMOUS-CELL CARCINOMA - CORRELATION WITH CLINICOPATHOLOGICAL FEATURES AND TUMOR-MARKERS, Oncology Reports, 5(4), 1998, pp. 871-874
Citations number
18
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
5
Issue
4
Year of publication
1998
Pages
871 - 874
Database
ISI
SICI code
1021-335X(1998)5:4<871:DOSPAI>2.0.ZU;2-A
Abstract
The significance of serum p53-Abs in patients with esophageal squamous cell carcinoma was determined. Examination of clinicopathological fea tures and assessment of tumor marker sensitivities of carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC-Ag) and CYFRA21-1 were performed. Thirty-three (58%) of 57 patients were positive for s erum p53-Abs, however, no relation with cancer progression existed. Fo urteen of the 33 sere-positive patients revealed normal levels of all tumor markers tested. Thus, serum p53-Abs appears to be a useful marke r for the detection of esophageal squamous cell carcinoma.