A METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM IS ASSOCIATED WITHEXPRESSION OF P16 IN HUMAN LUNG-CANCER

Citation
H. Kamiya et al., A METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM IS ASSOCIATED WITHEXPRESSION OF P16 IN HUMAN LUNG-CANCER, Oncology Reports, 5(4), 1998, pp. 911-914
Citations number
22
Categorie Soggetti
Oncology
Journal title
ISSN journal
1021335X
Volume
5
Issue
4
Year of publication
1998
Pages
911 - 914
Database
ISI
SICI code
1021-335X(1998)5:4<911:AMRPIA>2.0.ZU;2-G
Abstract
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in th e folate cycle. Reduced MTHFR activity induces DNA hypomethylation and stability, which may protect the tumor suppressor gene p16(INK4). We examined the association between MTHFR polymorphism and expression of p16(INK4). Th, frequency of the MTHFR genotypes were 21 Ala/Ala, 29 Al a/Aal, and 7 Val/Val. Expression of p16(INK4) was 26.2+/-26.8% in the Val/Val genotype and 11.21+/-16.6% in the other genotypes (p=0.46) as examined by immunostaining, and excluding four specimens that were ove rstained. These results suggest that folate metabolism can affect carc inogenesis through the expression of p16(INK4).